Severe Acute Liver Injury After Hepatotoxic Medication Initiation in Real-World Data.

ABSTRACT:

Importance

Current approaches to classify the hepatotoxic potential of medications are based on cumulative case reports of acute liver injury (ALI), which do not consider the size of the exposed population. There is little evidence from real-world data (data relating to patient health status and/or the delivery of health care routinely collected from sources outside of a research setting) on incidence rates of severe ALI after initiation of medications, accounting for duration of exposure.

Objective

To identify the most potentially hepatotoxic medications based on real-world incidence rates of severe ALI and to examine how these rates compare with categorization based on case reports.

Design, setting, and participants

This series of cohort studies obtained data from t

SUBMITTER: Torgersen J 

PROVIDER: S-EPMC11197444 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature