Internet and Telephone Support for Discontinuing Long-Term Antidepressants: The REDUCE Cluster Randomized Trial.

ABSTRACT:

Importance

There is significant concern regarding increasing long-term antidepressant treatment for depression beyond an evidence-based duration.

Objective

To determine whether adding internet and telephone support to a family practitioner review to consider discontinuing long-term antidepressant treatment is safe and more effective than a practitioner review alone.

Design, setting, and participants

In this cluster randomized clinical trial, 131 UK family practices were randomized between December 1, 2018, and March 31, 2022, with remote computerized allocation and 12 months of follow-up. Participants and researchers were aware of allocation, but analysis was blind. Participants were adults who were receiving antidepressants for more than 1 year for a first episode of

SUBMITTER: Kendrick T 

PROVIDER: S-EPMC11197448 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature