Sleep, 24-Hour Activity Rhythms, and Subsequent Amyloid-β Pathology.

ABSTRACT:

Importance

Sleep disturbances are common among older adults and have been associated with the development of Alzheimer disease (AD), such as amyloid-β (Aβ) pathology. For effective AD prevention, it is essential to pinpoint the specific disturbances in sleep and the underlying 24-hour activity rhythms that confer the highest risk of Aβ deposition.

Objective

To determine the associations of 24-hour activity rhythms and sleep with Aβ deposition in adults without dementia, to evaluate whether disrupted 24-hour activity and sleep may precede Aβ deposition, and to assess the role of the apolipoprotein E ε4 (APOE4) genotype.

Design, setting, and participants

This was an observational cohort study using data from the Rotterdam Study. Of 639 participants without dementia who

SUBMITTER: Nguyen Ho PT 

PROVIDER: S-EPMC11197458 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature