Activation of glutamatergic neurons in the somatosensory cortex promotes remyelination in ischemic vascular dementia.

ABSTRACT: Chronic cerebral hypoperfusion can cause progressive demyelination as well as ischemic vascular dementia, however no effective treatments are available. Here, based on magnetic resonance imaging studies of patients with white matter damage, we found that this damage is associated with disorganized cortical structure. In a mouse model, optogenetic activation of glutamatergic neurons in the somatosensory cortex significantly promoted oligodendrocyte progenitor cell (OPC) proliferation, remyelination in the corpus callosum, and recovery of cognitive ability after cerebral hypoperfusion. The therapeutic effect of such stimulation was restricted to the upper layers of the cortex, but also spanned a wide time window after ischemia. Mechanistically, enhancement of glutamatergic neuron-OPC functio

SUBMITTER: Zhou YT 

PROVIDER: S-EPMC11197523 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature