Using endogenous glycogen as relaxation agent for imaging liver metabolism by MRI.

ABSTRACT: Glycogen plays essential roles in glucose metabolism. Imaging glycogen in the liver, the major glycogen reservoir in the body, may shed new light on many metabolic disorders. ¹³C magnetic resonance spectroscopy (MRS) has become the mainstream method for monitoring glycogen in the body. However, the equipment of special hardware to standard clinical magnetic resonance imaging (MRI) scanners limits its clinical applications. Herein, we utilized endogenous glycogen as a T ₂-based relaxation contrast agent for imaging glycogen metabolism in the liver in vivo. The in vitro results demonstrated that the transverse relaxation rate of glycogen strongly correlates with the concentration, pH, and field strength. Based on the Swift-Connick theory, we charact

SUBMITTER: Chen S 

PROVIDER: S-EPMC11197538 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature