Pharmacological regulation of tissue fibrosis by targeting the mechanical contraction of myofibroblasts.

ABSTRACT: Fibrosis can occur in almost all tissues and organs and affects normal physiological function, which may have serious consequences, such as organ failure. However, there are currently no effective, broad-spectrum drugs suitable for clinical application. Revealing the process of fibrosis is an important prerequisite for the development of new therapeutic targets and drugs. Studies have shown that the limiting of myofibroblast activation or the promoting of their elimination can ameliorate fibrosis. However, it has not been reported whether a direct decrease in cell contraction can inhibit fibrosis in vivo. Here, we have shown that (-)-blebbistatin (Ble), a non-muscle myosin Ⅱ inhibitor, displayed significant inhibition of liver fibrosis in different chronic injury mouse models in

SUBMITTER: He ZQ 

PROVIDER: S-EPMC11197686 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature