Predicting dichotomised outcomes from high-dimensional data in biomedicine.

ABSTRACT: In many biomedical applications, we are more interested in the predicted probability that a numerical outcome is above a threshold than in the predicted value of the outcome. For example, it might be known that antibody levels above a certain threshold provide immunity against a disease, or a threshold for a disease severity score might reflect conversion from the presymptomatic to the symptomatic disease stage. Accordingly, biomedical researchers often convert numerical to binary outcomes (loss of information) to conduct logistic regression (probabilistic interpretation). We address this bad statistical practice by modelling the binary outcome with logistic regression, modelling the numerical outcome with linear regression, transforming the predicted values from linear regression to predi

SUBMITTER: Rauschenberger A 

PROVIDER: S-EPMC11198132 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature