Dataset Information

The generalized odd log-logistic-G regression with interval-censored survival data.

ABSTRACT: The article proposes a new regression based on the generalized odd log-logistic family for interval-censored data. The survival times are not observed for this type of data, and the event of interest occurs at some random interval. This family can be used in interval modeling since it generalizes some popular lifetime distributions in addition to its ability to present various forms of the risk function. The estimation of the parameters is addressed by the classical and Bayesian methods. We examine the behavior of the estimates for some sample sizes and censorship percentages. Selection criteria, likelihood ratio tests, residual analysis, and graphical techniques assess the goodness of fit of the fitted models. The usefulness of the proposed models is red shown by means of two real data sets.

SUBMITTER: Vigas VP

PROVIDER: S-EPMC11198143 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature

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The generalized odd log-logistic-G regression with interval-censored survival data.

Vigas Valdemiro P VP Ortega Edwin M M EMM Suzuki Adriano K AK Cordeiro Gauss M GM Dos Santos Junior Paulo C PC

Journal of applied statistics 20230712 9

The article proposes a new regression based on the generalized odd log-logistic family for interval-censored data. The survival times are not observed for this type of data, and the event of interest occurs at some random interval. This family can be used in interval modeling since it generalizes some popular lifetime distributions in addition to its ability to present various forms of the risk function. The estimation of the parameters is addressed by the classical and Bayesian methods. We exam ...[more]

PMID: 38933143

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Project description:BackgroundTime-to-event data that is subject to interval censoring is common in the practice of medical research and versatile statistical methods for estimating associations in such settings have been limited. For right censored data, non-parametric pseudo-observations have been proposed as a basis for regression modeling with the possibility to use different association measures. In this article, we propose a method for calculating pseudo-observations for interval censored data.MethodsWe develop an extension of a recently developed set of parametric pseudo-observations based on a spline-based flexible parametric estimator. The inherent competing risk issue with an interval censored event of interest necessitates the use of an illness-death model, and we formulate our method within this framework. To evaluate the empirical properties of the proposed method, we perform a simulation study and calculate pseudo-observations based on our method as well as alternative approaches. We also present an analysis of a real dataset on patients with implantable cardioverter-defibrillators who are monitored for the occurrence of a particular type of device failures by routine follow-up examinations. In this dataset, we have information on exact event times as well as the interval censored data, so we can compare analyses of pseudo-observations based on the interval censored data to those obtained using the non-parametric pseudo-observations for right censored data.ResultsOur simulations show that the proposed method for calculating pseudo-observations provides unbiased estimates of the cumulative incidence function as well as associations with exposure variables with appropriate coverage probabilities. The analysis of the real dataset also suggests that our method provides estimates which are in agreement with estimates obtained from the right censored data.ConclusionsThe proposed method for calculating pseudo-observations based on the flexible parametric approach provides a versatile solution to the specific challenges that arise with interval censored data. This solution allows regression modeling using a range of different association measures.

Dataset Information

The generalized odd log-logistic-G regression with interval-censored survival data.

Publications

The generalized odd log-logistic-G regression with interval-censored survival data.

Similar Datasets

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