Switching to external flows: perturbations of developing vasculature within chicken chorioallantoic membrane.

ABSTRACT: The impact of fluid flow shear stresses, generated by the movement of blood through vasculature, on the organization and maturation of vessels is widely recognized. Nevertheless, it remains uncertain whether external fluid flows outside of the vasculature in the surrounding tissue can similarly play a role in governing these processes. In this research, we introduce an innovative technique called superfusion-induced vascular steering (SIVS). SIVS involves the controlled imposition of external fluid flow patterns onto the vascularized chick chorioallantoic membrane (CAM), allowing us to observe how this impacts the organization of vascular networks. To investigate the concept of SIVS, we conducted superfusion experiments on the intact chick CAM cultured within an engineered eggshell system,

SUBMITTER: Padmanaban P 

PROVIDER: S-EPMC11198391 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature