Neutrophil to lymphocyte ratio in Alzheimer's disease: A systematic review and meta-analysis.

ABSTRACT:

Background

The Neutrophil-to-Lymphocyte Ratio (NLR) is a clinical indicator of peripheral inflammation that is easily accessible. It is worth noting that the formation of amyloid-β (Aβ) plaques and neurofibrillary tangles has been linked to inflammation and immune dysregulation. The main objective of this systematic review and meta-analysis is to comprehensively evaluate the existing body of research concerning the NLR in the context of Alzheimer's disease (AD) and mild cognitive impairment (MCI).

Method

We conducted a comprehensive online search and included studies that evaluated the NLR in 1) patients with AD or MCI and 2) healthy control (HC) participants. We also pooled mean and standard deviation (SD) data for each group.

Results

Ultimately, 12 studies encompass

SUBMITTER: Mohammadi A 

PROVIDER: S-EPMC11198755 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature