Impacts of age and environment on postnatal microglial activity: Consequences for cognitive function following early life adversity.

ABSTRACT: Early life adversity (ELA) increases the likelihood of later-life neuropsychiatric disorders and cognitive dysfunction. Importantly, ELA, neuropsychiatric disorders, and cognitive deficits all involve aberrant immune signaling. Microglia are the primary neuroimmune cells and regulate brain development. Microglia are particularly sensitive to early life insults, which can program their responses to future challenges. ELA in the form of maternal separation (MS) in rats alters later-life microglial morphology and the inflammatory profile of the prefrontal cortex, a region important for cognition. However, the role of microglial responses during MS in the development of later cognition is not known. Therefore, here we aimed to determine whether the presence of microglia during MS mediates long

SUBMITTER: Fanikos M 

PROVIDER: S-EPMC11198844 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature