Reconfigurations of cortical manifold structure during reward-based motor learning.

ABSTRACT: Adaptive motor behavior depends on the coordinated activity of multiple neural systems distributed across the brain. While the role of sensorimotor cortex in motor learning has been well established, how higher-order brain systems interact with sensorimotor cortex to guide learning is less well understood. Using functional MRI, we examined human brain activity during a reward-based motor task where subjects learned to shape their hand trajectories through reinforcement feedback. We projected patterns of cortical and striatal functional connectivity onto a low-dimensional manifold space and examined how regions expanded and contracted along the manifold during learning. During early learning, we found that several sensorimotor areas in the dorsal attention network exhibited increased covari

SUBMITTER: Nick Q 

PROVIDER: S-EPMC11198988 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature