Outcomes of Patients with a Mechanical Heart Valve and Poor Anticoagulation Control on Warfarin.

ABSTRACT:

Background

 Patients with a mechanical heart valve (MHV) require oral anticoagulation. Poor anticoagulation control is thought to be associated with adverse outcomes, but data are limited.

Objective

 To assess the risks of clinical outcomes in patients with a MHV and poor anticoagulation control on warfarin.

Methods

 We conducted a retrospective study of consecutive patients undergoing MHV implantation at a tertiary care center (2010-2019). Primary outcome was a composite of ischemic stroke, systemic embolism, or prosthetic valve thrombosis. Major bleeding and death were key secondary outcomes. We constructed multivariable regression models to assess the association between time in therapeutic range (TTR) on warfarin beyond 90 days after surgery with outcomes.

Resu

SUBMITTER: Johansson I 

PROVIDER: S-EPMC11199045 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature