Heritability of complex traits in sub-populations experiencing bottlenecks and growth.

ABSTRACT: Populations that have experienced a bottleneck are regularly used in Genome Wide Association Studies (GWAS) to investigate variants associated with complex traits. It is generally understood that these isolated sub-populations may experience high frequency of otherwise rare variants with large effect size, and therefore provide a unique opportunity to study said trait. However, the demographic history of the population under investigation affects all SNPs that determine the complex trait genome-wide, changing its heritability and genetic architecture. We use a simulation based approach to identify the impact of the demographic processes of drift, expansion, and migration on the heritability of complex trait. We show that demography has considerable impact on complex traits. We then investi

SUBMITTER: Taylor CS 

PROVIDER: S-EPMC11199143 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature