Serum Metabolomics Reveals Metabolomic Profile and Potential Biomarkers in Asthma.

ABSTRACT:

Purpose

Asthma is a highly heterogeneous disease. Metabolomics plays a pivotal role in the pathogenesis and development of asthma. The main aims of our study were to explore the underlying mechanism of asthma and to identify novel biomarkers through metabolomics approach.

Methods

Serum samples from 102 asthmatic patients and 18 healthy controls were collected and analyzed using liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS) system. Multivariate analysis and weighted gene co-expression network analysis (WGCNA) were performed to explore asthma-associated metabolomics profile and metabolites. The Kyoto Encyclopedia of Genes and Genomes (KEGG) was used for pathway enrichment analysis. Subsequently, 2 selected serum hub metabolites, myristoleic acid and dode

SUBMITTER: Zhu T 

PROVIDER: S-EPMC11199150 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature