Elevated extracellular particle concentration in plasma predicts in-hospital mortality after severe trauma.

ABSTRACT:

Background

Extracellular particles (EPs), particularly extracellular vesicles, play a crucial role in regulating various pathological mechanisms, including immune dysregulations post-trauma. Their distinctive expression of cell-specific markers and regulatory cargo such as cytokines or micro-ribonucleic acid suggests their potential as early biomarkers for organ-specific damage and for identifying patients at risk for complications and mortality. Given the critical need for reliable and easily assessable makers to identify at-risk patients and guide therapeutic decisions, we evaluated the early diagnostic value of circulating EPs regarding outcomes in severely injured multiple-trauma patients.

Methods

Plasma samples were collected from 133 severely injured trauma patients (I

SUBMITTER: Becker N 

PROVIDER: S-EPMC11199388 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature