Identification of drug targets for Sjogren's syndrome: multi-omics Mendelian randomization and colocalization analyses.

ABSTRACT:

Background

Targeted therapy for Sjögren's syndrome (SS) has become an important focus for clinicians. Multi-omics-wide Mendelian randomization (MR) analyses have provided new ideas for identifying potential drug targets.

Methods

We conducted summary-data-based Mendelian randomization (SMR) analysis to evaluate therapeutic targets associated with SS by integrating DNA methylation, gene expression and protein quantitative trait loci (mQTL, eQTL, and pQTL, respectively). Genetic associations with SS were derived from the FinnGen study (discovery) and the GWAS catalog (replication). Colocalization analyses were employed to determine whether two potentially relevant phenotypes share the same genetic factors in a given region. Moreover, to delve deeper into potential regulation am

SUBMITTER: Bai Y 

PROVIDER: S-EPMC11199405 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature