Empirical antifungal therapy for health care-associated intra-abdominal infection: a retrospective, multicentre and comparative study.

ABSTRACT:

Background

Current guidelines recommend using antifungals for selected patients with health care-associated intra-abdominal infection (HC-IAI), but this recommendation is based on a weak evidence. This study aimed to assess the association between early empirical use of antifungals and outcomes in intensive care unit (ICU) adult patients requiring re-intervention after abdominal surgery.

Methods

A retrospective, multicentre cohort study with overlap propensity score weighting was conducted in three ICUs located in three medical institutions in France. Patients treated with early empirical antifungals for HC-IAI after abdominal surgery were compared with controls who did not receive such antifungals. The primary endpoint was the death rate at 90 days, and the secondary endpoi

SUBMITTER: Mokart D 

PROVIDER: S-EPMC11199462 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature