Targeting a disintegrin and metalloprotease (ADAM) 17-CD122 axis enhances CD8⁺ T cell effector differentiation and anti-tumor immunity.

ABSTRACT: CD8⁺ T cell immune responses are regulated by multi-layer networks, while the post-translational regulation remains largely unknown. Transmembrane ectodomain shedding is an important post-translational process orchestrating receptor expression and signal transduction through proteolytic cleavage of membrane proteins. Here, by targeting the sheddase A Disintegrin and Metalloprotease (ADAM)17, we defined a post-translational regulatory mechanism mediated by the ectodomain shedding in CD8⁺ T cells. Transcriptomic and proteomic analysis revealed the involvement of post-translational regulation in CD8⁺ T cells. T cell-specific deletion of ADAM17 led to a dramatic increase in effector CD8⁺ T cell differentiation and enhanced cytolytic effects to elimin

SUBMITTER: Sun L 

PROVIDER: S-EPMC11199508 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature