The combined effect of lifestyle factors and polygenic scores on age at onset in Parkinson's disease.

ABSTRACT: The objective of this study was to investigate the association between a Parkinson's disease (PD)-specific polygenic score (PGS) and protective lifestyle factors on age at onset (AAO) in PD. We included data from 4367 patients with idiopathic PD, 159 patients with GBA1-PD, and 3090 healthy controls of European ancestry from AMP-PD, PPMI, and Fox Insight cohorts. The association between PGS and lifestyle factors on AAO was assessed with linear and Cox proportional hazards models. The PGS showed a negative association with AAO (β = - 1.07, p = 6 × 10^-7) in patients with idiopathic PD. The use of one, two, or three of the protective lifestyle factors showed a reduction in the hazard ratio by 21% (p = 0.0001), 44% (p < 2 × 10^-16), and 55% (p < 2 × 10^-16), compa

SUBMITTER: Gabbert C 

PROVIDER: S-EPMC11199580 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature