The zebrafish gut microbiome influences benzo[a]pyrene developmental neurobehavioral toxicity.

ABSTRACT: Early-life exposure to environmental toxicants like Benzo[a]pyrene (BaP) is associated with several health consequences in vertebrates (i.e., impaired or altered neurophysiological and behavioral development). Although toxicant impacts were initially studied relative to host physiology, recent studies suggest that the gut microbiome is a possible target and/or mediator of behavioral responses to chemical exposure in organisms, via the gut-brain axis. However, the connection between BaP exposure, gut microbiota, and developmental neurotoxicity remains understudied. Using a zebrafish model, we determined whether the gut microbiome influences BaP impacts on behavior development. Embryonic zebrafish were treated with increasing concentrations of BaP and allowed to grow to the larval life stage

SUBMITTER: Stagaman K 

PROVIDER: S-EPMC11199668 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature