A three-dimensional tissue-engineered rostral migratory stream as an in vitro platform for subventricular zone-derived cell migration.

ABSTRACT: In the brains of most adult mammals, neural precursor cells (NPCs) from the subventricular zone (SVZ) migrate through the rostral migratory stream (RMS) to replace olfactory bulb interneurons. Following brain injury, published studies have shown that NPCs can divert from the SVZ-RMS-OB route and migrate toward injured brain regions, but the quantity of arriving cells, the lack of survival and terminal differentiation of neuroblasts into neurons, and their limited capacity to re-connect into circuitry are insufficient to promote functional recovery in the absence of therapeutic intervention. Our lab has fabricated a biomimetic tissue-engineered rostral migratory stream (TE-RMS) that replicates some notable structural and functional components of the endogenous rat RMS. Based on the design a

SUBMITTER: Purvis EM 

PROVIDER: S-EPMC11199690 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature