Plasma metabolites as mediators in immune cell-pancreatic cancer risk: insights from Mendelian randomization.

ABSTRACT:

Background

Immune cells play a crucial role in the development and progression of pancreatic cancer, yet the causal relationship remains uncertain due to complex immune microenvironments and conflicting research findings. Mendelian randomization (MR), this study aims to delineate the causal relationships between immune cells and pancreatic cancer while identifying intermediary factors.

Methods

The genome-wide association study (GWAS) data on immune cells, pancreatic cancer, and plasma metabolites are derived from public databases. In this investigation, inverse variance weighting (IVW) as the primary analytical approach to investigate the causal relationship between exposure and outcome. Furthermore, this study incorporates MR-Egger, simple mode, weighted median, and weighte

SUBMITTER: Zhang K 

PROVIDER: S-EPMC11199692 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature