NLRP3 promotes allergic responses to birch pollen extract in a model of intranasal sensitization.

ABSTRACT:

Introduction & objective

Allergic sensitization is an essential step in the development of allergic airway inflammation to birch pollen (BP); however, this process remains to be fully elucidated. Recent scientific advances have highlighted the importance of the allergen context. In this regard, microbial patterns (PAMPs) present on BP have attracted increasing interest. As these PAMPs are recognized by specialized pattern recognition receptors (PRRs), this study aims at investigating the roles of intracellular PRRs and the inflammasome regulator NLRP3.

Methods

We established a physiologically relevant intranasal and adjuvant-free sensitization procedure to study BP-induced systemic and local lung inflammation.

Results

Strikingly, BP-sensitized Nlrp3-deficient m

SUBMITTER: Bauer R 

PROVIDER: S-EPMC11199694 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature