A novel signature constructed by mitochondrial function and cell death-related gene for the prediction of prognosis in bladder cancer.

ABSTRACT: Bladder urothelial carcinoma (BLCA) presents a persistent challenge in clinical management. Despite recent advancements demonstrating the BLCA efficacy of immune checkpoint inhibitors (ICI) in BLCA patients, there remains a critical need to identify and expand the subset of individuals who benefit from this treatment. Mitochondria, as pivotal regulators of various cell death pathways in eukaryotic cells, exert significant influence over tumor cell fate and survival. In this study, our objective was to investigate biomarkers centered around mitochondrial function and cell death mechanisms to facilitate prognostic prediction and guide therapeutic decision-making in BLCA. Utilizing ssGSEA and LASSO regression, we developed a prognostic signature termed mitochondrial function and cell death (m

SUBMITTER: Yan Z 

PROVIDER: S-EPMC11199696 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature