Data-driven queries between medications and spontaneous preterm birth among 2.5 million pregnancies.

ABSTRACT:

Background

Our goal was to develop an approach that can systematically identify potential associations between medication prescribed in pregnancy and spontaneous preterm birth (sPTB) by mining large administrative "claims" databases containing hundreds of medications. One such association that we illustrate emerged with antiviral medications used for herpes treatment.

Methods

IBM MarketScan® databases (2007-2016) were used. A pregnancy cohort was established using International Classification of Diseases (ICD-9/10) codes. Multiple hypothesis testing and the Benjamini-Hochberg procedure that limited false discovery rate at 5% revealed, among 863 medications, five that showed odds ratios (ORs) <1. The statistically strongest was an association between antivirals and sPTB that

SUBMITTER: Maric I 

PROVIDER: S-EPMC11199711 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature