An integrative sensor of body states: how the mushroom body modulates behavior depending on physiological context.

ABSTRACT: The brain constantly compares past and present experiences to predict the future, thereby enabling instantaneous and future behavioral adjustments. Integration of external information with the animal's current internal needs and behavioral state represents a key challenge of the nervous system. Recent advancements in dissecting the function of the Drosophila mushroom body (MB) at the single-cell level have uncovered its three-layered logic and parallel systems conveying positive and negative values during associative learning. This review explores a lesser-known role of the MB in detecting and integrating body states such as hunger, thirst, and sleep, ultimately modulating motivation and sensory-driven decisions based on the physiological state of the fly. State-dependent signals pr

SUBMITTER: Suarez-Grimalt R 

PROVIDER: S-EPMC11199956 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature