Synergistic upregulation of PD‑L1 in tumor cells and CD39 in tumor‑infiltrating CD8⁺ T cells leads to poor prognosis in patients with hepatocellular carcinoma.

ABSTRACT: The immune escape of tumor cells and functional status of tumor-infiltrating T cells may serve pivotal roles in the tumor immune microenvironment and progression of hepatocellular carcinoma (HCC). The present study enrolled 91 patients with HCC and examined programmed cell death ligand 1 (PD-L1) expression in tumor cells and CD39 expression in tumor-infiltrating CD8⁺ T cells in patient samples using multiplex immunofluorescence assays. The impact of PD-L1 and CD39 expression levels on the prognosis of patients with HCC was investigated utilizing Kaplan-Meier analyses. The individual upregulation of PD-L1 in tumor cells, as well as the individual upregulation of CD39 expression in tumor-infiltrating CD8⁺ T cells did not significantly affect the prognosis of patients wi

SUBMITTER: Kang X 

PROVIDER: S-EPMC11200054 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature