Escalated-dose radiotherapy for unresected locally advanced pancreatic cancer: Patterns of care and survival in the United States.

ABSTRACT:

Introduction

With locally advanced pancreatic cancer (LAPC), uncontrolled local tumor growth frequently leads to mortality. Advancements in radiotherapy (RT) techniques have enabled conformal delivery of escalated-dose RT (EDR), which may have potential local control and overall survival (OS) benefits based on retrospective and early prospective studies. With evidence for EDR emerging, we characterized the adoption of EDR across the United States and its associated outcomes.

Methods

We searched the National Cancer Database for nonsurgically managed LAPC patients diagnosed between 2004 and 2019. Pancreas-directed RT with biologically effective doses (BED₁₀) ≥39 and ≤70 Gy was labeled conventional-dose RT (CDR), and BED₁₀ >70 and ≤132 Gy was labeled EDR.

SUBMITTER: Shi C 

PROVIDER: S-EPMC11200087 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature