The establishment of kidney cancer organoid line in drug testing.

ABSTRACT:

Introduction

Kidney cancer is a common urological malignancy worldwide with an increasing incidence in recent years. Among all subtypes, renal cell carcinoma (RCC) represents the most predominant malignancy in kidney. Clinicians faced a major challenge to select the most effective and suitable treatment regime for patients from a wide range of modalities, despite improved understanding and diagnosis of RCC.

Objective

Recently, organoid culture gained more interest as the 3D model is shown to be highly patient specific which is hypothetically beneficial to the investigation of precision medicine. Nonetheless, the development and application of organotypic culture in RCC is still immature, therefore, the primary objective of this study was to establish an organoid model for RC

SUBMITTER: Tse RT 

PROVIDER: S-EPMC11200131 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature