Gradual ER calcium depletion induces a progressive and reversible UPR signaling.

ABSTRACT: The unfolded protein response (UPR) is a widespread signal transduction pathway triggered by endoplasmic reticulum (ER) stress. Because calcium (Ca²⁺) is a key factor in the maintenance of ER homeostasis, massive Ca²⁺ depletion of the ER is a potent inducer of ER stress. Although moderate changes in ER Ca²⁺ drive the ubiquitous Ca²⁺ signaling pathways, a possible incremental relationship between UPR activation and Ca²⁺ changes has yet to be described. Here, we determine the sensitivity and time-dependency of activation of the three ER stress sensors, inositol-requiring protein 1 alpha (IRE1α), protein kinase R-like ER kinase (PERK), and activating transcription factor 6 alpha (ATF6α) in response to controlled changes in the concentrati

SUBMITTER: Pontisso I 

PROVIDER: S-EPMC11200134 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature