Clinical Outcomes for BRCA Pathogenic Variant Carriers With Breast Cancer Undergoing Breast Conservation.

ABSTRACT:

Importance

Although most women with BRCA-associated breast cancer choose bilateral mastectomy, current guidelines support breast-conserving therapy as an option. As the indications for genetic testing expand and targeted therapies emerge, understanding the outcomes of breast-conserving therapy in the population of patients choosing breast conservation is important.

Objective

To describe the clinical outcomes of women with BRCA-associated breast cancer who were treated with breast-conserving therapy, including the risks of ipsilateral and contralateral cancer events and bilateral mastectomy-free survival.

Design, setting, and participants

This cohort study conducted at a single-institution academic national comprehensive cancer center included 172 women identified from

SUBMITTER: Wanis KN 

PROVIDER: S-EPMC11200147 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature