RhoMax: Computational Prediction of Rhodopsin Absorption Maxima Using Geometric Deep Learning.

ABSTRACT: Microbial rhodopsins (MRs) are a diverse and abundant family of photoactive membrane proteins that serve as model systems for biophysical techniques. Optogenetics utilizes genetic engineering to insert specialized proteins into specific neurons or brain regions, allowing for manipulation of their activity through light and enabling the mapping and control of specific brain areas in living organisms. The obstacle of optogenetics lies in the fact that light has a limited ability to penetrate biological tissues, particularly blue light in the visible spectrum. Despite this challenge, most optogenetic systems rely on blue light due to the scarcity of red-shifted opsins. Finding additional red-shifted rhodopsins would represent a major breakthrough in overcoming the challenge of limited light p

SUBMITTER: Sela M 

PROVIDER: S-EPMC11200256 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature