An integrated database of experimentally validated major histocompatibility complex epitopes for antigen-specific cancer therapy.

ABSTRACT: Cancer immunotherapy represents a paradigm shift in oncology, offering a superior anti-tumor efficacy and the potential for durable remission. The success of personalized vaccines and cell therapies hinges on the identification of immunogenic epitopes capable of eliciting an effective immune response. Current limitations in the availability of immunogenic epitopes restrict the broader application of such therapies. A critical criterion for serving as potential cancer antigens is their ability to stably bind to the major histocompatibility complex (MHC) for presentation on the surface of tumor cells. To address this, we have developed a comprehensive database of MHC epitopes, experimentally validated for their MHC binding and cell surface presentation. Our database catalogs 451 065 MHC pept

SUBMITTER: Kawakita S 

PROVIDER: S-EPMC11200702 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature