Diagnostic performance of plasma pTau₂₁₇, pTau₁₈₁, Aβ_1-42 and Aβ_1-40 in the LUMIPULSE automated platform for the detection of Alzheimer disease.

ABSTRACT:

Background

Recently developed blood markers for Alzheimer's disease (AD) detection have high accuracy but usually require ultra-sensitive analytic tools not commonly available in clinical laboratories, and their performance in clinical practice is unknown.

Methods

We analyzed plasma samples from 290 consecutive participants that underwent lumbar puncture in routine clinical practice in a specialized memory clinic (66 cognitively unimpaired, 130 participants with mild cognitive impairment, and 94 with dementia). Participants were classified as amyloid positive (A +) or negative (A-) according to CSF Aβ_1-42/Aβ_1-40 ratio. Plasma pTau₂₁₇, pTau₁₈₁, Aβ_1-42 and Aβ_1-40 were measured in the fully-automated LUMIPULSE pl

SUBMITTER: Arranz J 

PROVIDER: S-EPMC11200993 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature