Metabolite signature of diabetes remission in individuals with obesity undergoing weight loss interventions.

ABSTRACT:

Objective

This observational study investigated metabolomic changes in individuals with type 2 diabetes (T2D) after weight loss. We hypothesized that metabolite changes associated with T2D-relevant phenotypes are signatures of improved health.

Methods

Fasting plasma samples from individuals undergoing bariatric surgery (n = 71 Roux-en-Y gastric bypass [RYGB], n = 22 gastric banding), lifestyle intervention (n = 66), or usual care (n = 14) were profiled for 139 metabolites before and 2 years after weight loss. Principal component analysis grouped correlated metabolites into factors. Association of preintervention metabolites was tested with preintervention clinical features and changes in T2D markers. Association between change in metabolites/metabolite factors and change in

SUBMITTER: Thaker VV 

PROVIDER: S-EPMC11201087 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature