Association between depression and young-onset dementia in middle-aged women.

ABSTRACT:

Background

Dementia is associated with older adults; however, it can also affect younger individuals, known as young-onset dementia (YOD), when diagnosed before the age of 65 years. We aimed to conduct a retrospective cohort study involving middle-aged women to investigate the association between premorbid depression and YOD development.

Methods

We included 1.6 million women aged 40-60 years who underwent health checkups under the Korean National Health Insurance Service and investigated the association between depression and YOD.

Results

Women with depression had a significantly higher risk of developing YOD than women without depression. Among premenopausal women, those with depression had a 2.67-fold increased risk, whereas postmenopausal women with depression had

SUBMITTER: Yoo JE 

PROVIDER: S-EPMC11201295 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature