Simulation of Radiation-Induced DNA Damage and Protection by Histones Using the Code RITRACKS.

ABSTRACT: (1) Background: DNA damage is of great importance in the understanding of the effects of ionizing radiation. Various types of DNA damage can result from exposure to ionizing radiation, with clustered types considered the most important for radiobiological effects. (2) Methods: The code RITRACKS (Relativistic Ion Tracks), a program that simulates stochastic radiation track structures, was used to simulate DNA damage by photons and ions spanning a broad range of linear energy transfer (LET) values. To perform these simulations, the transport code was modified to include cross sections for the interactions of ions or electrons with DNA and amino acids for ionizations, dissociative electron attachment, and elastic collisions. The radiochemistry simulations were performed using a step-by-step a

SUBMITTER: Plante I 

PROVIDER: S-EPMC11201919 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature