The Immune Checkpoint Protein PD-L1 Regulates Ciliogenesis and Hedgehog Signaling.

ABSTRACT: The primary cilium, an antenna-like sensory organelle that protrudes from the surface of most eukaryotic cell types, has become a signaling hub of growing interest given that defects in its structure and/or function are associated with human diseases and syndromes, known as ciliopathies. With the continuously expanding role of primary cilia in health and diseases, identifying new players in ciliogenesis will lead to a better understanding of the function of this organelle. It has been shown that the primary cilium shares similarities with the immune synapse, a highly organized structure at the interface between an antigen-presenting or target cell and a lymphocyte. Studies have demonstrated a role for known cilia regulators in immune synapse formation. However, whether immune synapse regul

SUBMITTER: Agborbesong E 

PROVIDER: S-EPMC11201989 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature