Proteomic profiling of prostate cancer reveals molecular signatures under antiandrogen treatment.

ABSTRACT:

Background

Tumorigenesis and progression of prostate cancer (PCa) are indispensably dependent on androgen receptor (AR). Antiandrogen treatment is the principal preference for patients with advanced PCa. However, the molecular characteristics of PCa with antiandrogen intervention have not yet been fully uncovered.

Methods

We first performed proteome analysis with 32 PCa tumor samples and 10 adjacent tissues using data-independent acquisition (DIA)- parallel accumulation serial fragmentation (PASEF) proteomics. Then label-free quantification (LFQ) mass spectrometry was employed to analyze protein profiles in LNCaP and PC3 cells.

Results

M-type creatine kinase CKM and cartilage oligomeric matrix protein COMP were demonstrated to have the potential to be diagnostic bioma

SUBMITTER: Huang Y 

PROVIDER: S-EPMC11202386 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature