Comparing gene expression profiles of adults with isolated spinal tuberculosis to disseminated spinal tuberculosis identified by ¹⁸FDG-PET/CT at time of diagnosis, 6- and 12-months follow-up: classifying clinical stages of spinal tuberculosis and monitoring treatment response (Spinal TB X cohort study).

ABSTRACT:

Background

Tuberculosis (TB) is one of the top ten causes of death worldwide, with approximately 10 million cases annually. Focus has been on pulmonary TB, while extrapulmonary TB (EPTB) has received little attention. Diagnosis of EPTB remains challenging due to the invasive procedures required for sample collection. Spinal TB (STB) accounts for 10% of EPTB and often leads to lifelong debilitating disease due to devastating spinal deformation and compression of neural structures. Little is known about the extent of disease, although both isolated STB and a disseminated form of STB have been described. In our Spinal TB X cohort study, we aim to describe the clinical phenotype of STB using whole-body ¹⁸FDG-PET/CT, identify a specific gene expression profile for different s

SUBMITTER: Scherer J 

PROVIDER: S-EPMC11202394 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature