Real-World Safety of Niraparib for Maintenance Treatment of Ovarian Cancer in Canada.

ABSTRACT: Niraparib was recently funded in Canada for the maintenance treatment of ovarian cancer following platinum-based chemotherapy. However, the drug's safety profile in the real world remains uncertain. We conducted a cohort study to describe the patient population using niraparib and the proportion that experienced adverse events between June 2019 and December 2022 in four Canadian provinces (Ontario, Alberta, British Columbia [BC], and Quebec). We used administrative data and electronic medical records from Ontario Health, Alberta Health Services, and BC Cancer, and registry data from Exactis Innovation. We summarized baseline characteristics using descriptive statistics and reported safety outcomes using cumulative incidence. We identified 514 patients receiving niraparib. Mean age was 67 y

SUBMITTER: Guan Q 

PROVIDER: S-EPMC11202616 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature