Umbrella review of risk factors for inflammatory bowel disease: a study protocol.

ABSTRACT:

Introduction

Inflammatory bowel disease (IBD) is a chronic idiopathic inflammatory disorder that arises from complex interactions between genetics, environment and gut microbiota. It encompasses Crohn's disease, ulcerative colitis and IBD-unclassified. The protracted course of IBD imposes a significant burden on patients' quality of life, economic productivity, social functioning, as well as treatment, hospitalisation and surgery. This study aims to conduct an umbrella review of meta-analyses to systematically evaluate the methodology's quality, potential biases and validity of all epidemiological evidence focused on risk factors for IBD while providing an overview of the evidence concerning IBD risk factors.

Methods and analysis

We will systematically search, extract and an

SUBMITTER: Jian M 

PROVIDER: S-EPMC11202652 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature