Low Levels of IgM Recognizing 4-Hydroxy-2-Nonenal-Modified Apolipoprotein A-I Peptide and Its Association with the Severity of Coronary Artery Disease in Taiwanese Patients.

ABSTRACT: Autoantibodies against apolipoprotein A-I (ApoA-I) are associated with cardiovascular disease risks. We aimed to examine the 4-hydroxy-2-nonenal (HNE) modification of ApoA-I in coronary artery disease (CAD) and evaluate the potential risk of autoantibodies against their unmodified and HNE-modified peptides. We assessed plasma levels of ApoA-I, HNE-protein adducts, and autoantibodies against unmodified and HNE-peptide adducts, and significant correlations and odds ratios (ORs) were examined. Two novel CAD-specific HNE-peptide adducts, ApoA-I^251-262 and ApoA-I^70-83, were identified. Notably, immunoglobulin G (IgG) anti-ApoA-I^251-262 HNE, IgM anti-ApoA-I^70-83 HNE, IgG anti-ApoA-I^251-262, IgG anti-ApoA-I^70-83, and HNE-protein ad

SUBMITTER: Lei MH 

PROVIDER: S-EPMC11202877 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature