Genomic Evolution Strategy in SARS-CoV-2 Lineage B: Coevolution of Cis Elements.

ABSTRACT: In the SARS-CoV-2 lineage, RNA elements essential for its viral life cycle, including genome replication and gene expression, have been identified. Still, the precise structures and functions of these RNA regions in coronaviruses remain poorly understood. This lack of knowledge points out the need for further research to better understand these crucial aspects of viral biology and, in time, prepare for future outbreaks. In this research, the in silico analysis of the cis RNA structures that act in the alpha-, beta-, gamma-, and deltacoronavirus genera has provided a detailed view of the presence and adaptation of the structures of these elements in coronaviruses. The results emphasize the importance of these cis elements in viral biology and their variability between differen

SUBMITTER: Tamayo-Ordonez YJ 

PROVIDER: S-EPMC11203041 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature