Use of immunosuppression and subsequent cancer incidence: cohort study.

ABSTRACT:

Objective

Evaluate the association between cancer incidence and immunosuppressive treatment in patients with ocular inflammatory disease (OID).

Methods and analysis

We performed a retrospective cohort study of patients from 10 US OID subspecialty practices. Patients with non-infectious OID were included; HIV-infected patients were excluded. Time-dependent exposure to drug classes (ie, antimetabolites, calcineurin inhibitors, alkylating agents, tumour necrosis factor (TNF) inhibitors) and drugs were evaluated. Cancer incidence was ascertained by linkage to 12 state cancer registries from 1996 to 2015. Cancer incidence was analysed using Cox regression survival analysis, using 0-year, 3-year and 5-year lags after immunosuppression began.

Results

The cancer incidence coh

SUBMITTER: Buchanich JM 

PROVIDER: S-EPMC11203086 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature