Statistical Considerations for the Design and Analysis of Pragmatic Trials in Aging Research.

ABSTRACT: Pragmatic trials aim to assess intervention efficacy in usual patient care settings, contrasting with explanatory trials conducted under controlled conditions. In aging research, pragmatic trials are important designs for obtaining real-world evidence in elderly populations, which are often underrepresented in trials. In this review, we discuss statistical considerations from a frequentist approach for the design and analysis of pragmatic trials. When choosing the dependent variable, it is essential to use an outcome that is highly relevant to usual medical care while also providing sufficient statistical power. Besides traditionally used binary outcomes, ordinal outcomes can provide pragmatic answers with gains in statistical power. Cluster randomization requires careful consideration of

SUBMITTER: Kammar-Garcia A 

PROVIDER: S-EPMC11203240 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature