Causal relationship between gut microbiota and puerperal sepsis: a 2-sample Mendelian randomization study.

ABSTRACT:

Background

Some recent observational studies have shown that gut microbiota composition is associated with puerperal sepsis (PS) and no causal effect have been attributed to this. The aim of this study was to determine a causal association between gut microbiota and PS by using a two-sample Mendelian randomization (MR) analysis.

Methods

This study performed MR analysis on the publicly accessible genome-wide association study (GWAS) summary level data in order to explore the causal effects between gut microbiota and PS. Gut microbiota GWAS (n = 18,340) were obtained from the MiBioGen study and GWAS-summary-level data for PS were obtained from the UK Biobank (PS, 3,940 cases; controls, 202,267 cases). Identification of single nucleotide polymorphisms associated with eac

SUBMITTER: Liang LD 

PROVIDER: S-EPMC11203603 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature