<i>Alcaligenes faecalis</i> corrects aberrant matrix metalloproteinase expression to promote reepithelialization of diabetic wounds.

ABSTRACT: Chronic wounds are a common and costly complication of diabetes, where multifactorial defects contribute to dysregulated skin repair, inflammation, tissue damage, and infection. We previously showed that aspects of the diabetic foot ulcer microbiota were correlated with poor healing outcomes, but many microbial species recovered remain uninvestigated with respect to wound healing. Here, we focused on Alcaligenes faecalis, a Gram-negative bacterium that is frequently recovered from chronic wounds but rarely causes infection. Treatment of diabetic wounds with A. faecalis accelerated healing during early stages. We investigated the underlying mechanisms and found that A. faecalis treatment promotes reepithelialization of diabetic keratinocytes, a process that is necessary

SUBMITTER: White EK 

PROVIDER: S-EPMC11204295 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature