New Secondary Metabolites from Marine-Derived Fungus Talaromyces minnesotensis BTBU20220184.

ABSTRACT: Six new compounds, talamitones A and B (1 and 2), demethyltalamitone B (3), talamiisocoumaringlycosides A and B (4 and 5), and talaminaphtholglycoside (6), together with six known compounds (7-12), were isolated from the marine-derived fungus Talaromyces minnesotensis BTBU20220184. The new structures were characterized by using HRESIMS and NMR. This is the first report of isocoumaringlycoside derivatives from a fungus of the Talaromyces genus. Compounds 5, 6, and 9 showed synergistic antibacterial activity against Staphylococcus aureus.

SUBMITTER: Wang W 

PROVIDER: S-EPMC11204780 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature